The T-cell receptor repertoire of regulatory T cells
نویسندگان
چکیده
منابع مشابه
The T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed toward public sequences.
The accumulation of CD4(+) T regulatory cells (Treg) in tumor tissue is a widely described phenomenon in mouse models and in human cancer patients. Understanding the mechanisms by which Treg migrate and accumulate in tumors is important because they strongly influence the potential efficacy of many immunotherapies. In this study, we used immunoscope technology to analyze the T-cell receptor (TC...
متن کاملRegulatory T Cells in Colorectal Cancer
One of the essential protection mechanisms of immune system is Treg cells which play an important role in maintenance ofimmune homeostasis. However, they may also inhibit immune functions against tumor cells. It has been reported that Treg cellsare increased in patients suffering from different types of cancer. Increased number of Treg cells has been shown in tumor lymphnodes, peripheral blood,...
متن کاملEvaluation of Exhausted Regulatory T Cells in Preeclampsia
Background: The development of a maternal immune response to fetal antigens and deficiency in regulatory T-cells (Tregs) may lead to preeclampsia. A plausible explanation for the reduced Treg cell function in women with preeclampsia is the presence of exhausted Treg cells which express CD279 or programmed cell death receptor-1 (PD-1), a negative regulatory molecule associated w...
متن کاملT Helper Cells Profile and CD4+CD25+Foxp3+Regulatory T Cells in Polycystic Ovary Syndrome
Background: Polycystic ovary syndrome (PCOS) is considered as the most common cause of female infertility that affects 4-10% of women in the reproductive age. Previous studies have shown the role of a balanced immune response in a successful pregnancy and fertility. Objective: To investigate the T helper cells type 1 (Th1) /Th2/Th17/Treg paradigms in peripheral blood of infertile PCOS compared ...
متن کاملThe T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed towards public sequences Short title: T-cell repertoire of tumor-infiltrating Treg Authors
184 words Figure/ table count: 7 figures / tables Reference count: 40 Disclosure of potential conflicts of interest: The authors have no conflicting interests. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. ABSTRACT The accumulation of CD4 + T regulatory cells (Treg) in tumor tissue is a widely described phenomenon in mouse models and in hu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunology
سال: 2008
ISSN: 0019-2805,1365-2567
DOI: 10.1111/j.1365-2567.2008.02992.x